GRM3 Gene

Metabotropic Glutamate Receptor-3 (GRM3) is a candidate gene for schizophrenia.

Metabotropic Glutamate Receptor-3 (GRM3) is a candidate gene for schizophrenia.

Metabotropic Glutamate Receptor-3 (GRM3) is a G-protein coupled receptor for glutamate, a major excitatory neurotransmitter. GRM3 also modulates serotonin and dopamine transmission. Several association studies have linked GRM3 polymorphisms to schizophrenia, suggesting functional changes in glutamate transmission in the prefrontal cortex and hippocampus.