SNAP25/A0333

Synaptosomal-associated protein 25 (SNAP25), also known as Super protein or A0333, is a neural specific protein involved in synaptic vesicle docking and fusion process.

Synaptosomal-associated protein 25 (SNAP25), also known as Super protein or A0333, is a neural specific protein involved in synaptic vesicle docking and fusion process. SNAP25 regulates the membrane potential and the calcium entry not only by the exocytic pathway but also by interaction with the rectifier potassium channels. SNAP25 belongs to the SNAP25 family and it is mostly expressed in the hippocampus, specifically in the presynaptic membrane. SNAP25 forms part of the SNARE complex with synaptobrevin and syntaxin. SNAP25 contains two t-SNARE coiled coil domains and one cysteine-rich region. Splicing generates two isoforms, SNAP25A and SNAP25B, by usage of two alternative homologous exons. Homozygous SNAP25 knock-out mice are lethal. Heterozygous mice show a hyperactive phenotype similar to attention deficit/hyperactivity disorder (ADHD). The human SNAP25 gene maps to chromosome 20, band p11.2. The levels of SNAP25 in hippocampus are reduced in schizophrenia patients compared to controls.