PSD93/A0014

Post-synaptic density protein 93 (PSD93), also known as channel-associated protein of synapse-110 (Chapsyn-110) or A0014, is a scaffold protein that belongs to the membrane-associated guanylate kinase (MAGUK) family (PSD93, PSD95, SAP97, SAP102).

Post-synaptic density protein 93 (PSD93), also known as channel-associated protein of synapse-110 (Chapsyn-110) or A0014, is a scaffold protein that belongs to the membrane-associated guanylate kinase (MAGUK) family (PSD93, PSD95, SAP97, SAP102). The protein is mainly expressed in brain tissue, where alternative splicing produces eight different isoforms. In contrast to other members of the MAGUK family, PSD93 is expressed in Purkinje cell bodies and dendrites. The predicted 852 amino acid sequence contains three PDZ domains, a SH3 domain, and a guanylate kinase-homology domain that interact with receptors, potassium channels and associated signaling proteins. PSD93 and PSD95 heteromultimerize to cluster N-methyl-D-aspartate (NMDA) receptor and potassium channels. PSD93 knock-out mice show no structural or functional abnormalities in the cerebellum. Post-synaptic Purkinje responses and cerebellum-mediated behavior are also normal. The human PSD93 gene maps to the chromosome position 11q21. Recently, microdeletion of the gene was found in schizophrenia patients.