SRC kinase/A0018

SRC kinase, also known as A0018, is a member of the SRC family of kinases (SFK).

SRC kinase, also known as A0018, is a member of the SRC family of kinases (SFK). The SRC gene is homologous in sequence to the v-SRC gene of the Rous sarcoma virus. SFK kinases were initially involved in regulation of cell proliferation and differentiation. SRC has been implicated in proliferation and differentiation during the development of the central nervous system (CNS). However, SRC is highly expressed in fully differentiated neurons in the developed CNS, implying additional functions of this kinase. It has become evident that one major function of SRC in the developed CNS is to regulate the activity of ion channels, mainly the N-methyl-D-aspartate receptor (NMDAR). This kinase has been shown to regulate other types of channels in neurons, including voltage-gated ion channels, such as potassium channels and calcium channels, and ionotropic neurotransmitter receptors, including gamma-amino butyric acid (GABA)-A and nicotinic acetylcholine and beta-2 adrenergic receptors . The activation of SRC induces the phosphorylation of several tyrosines of the NR2 subunits of the NMDAR, this phosphorylation generally is related to the up-regulation of NMDAR function, thereby gating the production of NMDAR-dependent synaptic potentiation. Histological examination of homozygous mutants of SRC did not reveal detectable abnormalities in the brain. However, these mutants were deficient in bone remodeling, indicating impaired osteoclast function.