PTK2B/A0030

PTK2B, also known as PYK2 or A0030, is a member of the focal adhesion kinase (FAK) family.

PTK2B, also known as PYK2 or A0030, is a member of the focal adhesion kinase (FAK) family. They are cytoplasmic protein-tyrosine kinases associated with focal adhesions and whose activity is induced by ligand binding to various receptors including those for integrin and growth factors. PYK2 is activated by a variety of extracellular stimuli, including stimuli that elevate the cytoplasmic free calcium ion concentration like activation of N-methyl-D-aspartate receptor (NMDAR) or nicotinic acetylcholine receptor or membrane depolarization The activation of PYK2 in response to rise of intracellular calcium ion concentration is mediated by protein kinase C (PKC), calmodulin (CaM), CaM-dependent kinase II (CaMKII). Upon stimulation, PYK2 undergoes autophosphorylation, which induces its activation PYK2. Activated PYK2 recruits and activates, then SRC family kinases phosphorylate PYK2, this phosphorylation is required for full activation of PYK2. PYK2 is implicated as an upstream activator kinase in several intracellular signaling cascades, such as the extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK), p38 MAPK and C-Jun N-terminal kinase (JNK) pathways, PYK2 also acts as a scaffold protein and is associated in many cell types with various proteins, including 3-phosphoinositide-dependent protein kinase 1 (PDK1) and phospholipase D2. PYK2-null mice were normal in appearance and body weight; these mice have high bone mass resulting from an unexpected increase in bone formation. In the immune system this mutation causes abnormal macrophage physiology and decreased acute