PKACB/A4037

The cyclic adenosine monophosphate (cAMP)-dependent protein kinase catalytic subunit beta, also known as PKACB or A4037, is one of the catalytic subunits of protein kinase A (PKA).

The cyclic adenosine monophosphate (cAMP)-dependent protein kinase catalytic subunit beta, also known as PKACB or A4037, is one of the catalytic subunits of protein kinase A (PKA). PKA belongs to the AGC group of serine/threonine kinases and exists as tetramer consisting of two regulatory (R) and two catalytic (C) subunits, Four genes encode the R subunits (RIα, RIß, RIIα, and RIIß), and three encode the C subunits (Cα, Cß and Cγ). The enzyme is activated by the binding of cAMP to the R subunits, inducing the dissociation of the interaction between the R and C subunits. The PKACB gene encodes three isoforms (Cß1,2 and 3). Knocking-out all three isoforms in mice has no effect on total PKA activity in the hippocampus and amygdale. These mice present a strain-specific impairment in the cued fear conditioning test, but normal contextual fear conditioning, locomotor activity, and conditioned taste aversion tests.