GNB4/A0072

Guanine nucleotide binding protein, beta 4 (GNB4), also known as A0072, is a member of the heterotrimeric guanine nucleotide-binding proteins (G proteins), which act as a modulator or transducer in various transmembrane signaling systems and relay ...

Guanine nucleotide binding protein, beta 4 (GNB4), also known as A0072, is a member of the heterotrimeric guanine nucleotide-binding proteins (G proteins), which act as a modulator or transducer in various transmembrane signaling systems and relay signals from cell surface receptors to internal effectors. G proteins are composed of 3 subunits: alpha, beta and gamma. The beta and gamma chains are required for the GTPase activity, for replacement of guanosine diphosphate (GDP) by guanosine triphosphate (GTP), and for G protein-effector interaction. The alpha subunit is a GTPase that interacts in the GDP-bound state with beta-gamma dimmers. Like other beta subunits, GNB4 contains 7 WD repeats forming a beta-propeller structure. In humans, GNB4 is strongly expressed in the lung, pancreas and placenta, moderate expression in kidney and liver, and weakly expressed in the brain and heart.