CDH2/A0219

Cadherin-2 precursor (CDH2), or neuronal cadherin (N-cadherin), also known as A0219, is a single pass type 1 membrane protein, which contains five cadherin domains.

Cadherin-2 precursor (CDH2), or neuronal cadherin (N-cadherin), also known as A0219, is a single pass type 1 membrane protein, which contains five cadherin domains. Cadherin are a family of calcium-dependent cell adhesion molecules. Within the cadherin protein family, CDH2/N-cadehrin is associated with alpha- and beta-catenin but not with E-cadherin (CDH1) or P-cadherin (CDH3). CDH2 is involved in the neuronal recognition system and may be involved in both pre- and post-synaptic adhesion. The adhesion may be controlled by synaptic activity. Homozygous mouse mutants of CDH2 die by E10. Mutant embryos exhibit a range of developmental abnormalities such as growth retardation, heart and neural tube development defects. Chimeric mutant mice with dominant-negative CDH2 show defects in crypt-villus development, providing a model for inflammatory bowel disease.