GRM/A0327

GRM1, also known as A0327, is a non-ionotropic G-coupled protein glutamate receptor.

GRM1, also known as A0327, is a non-ionotropic G-coupled protein glutamate receptor. It is localized post-synaptically and functionally couples to the phospholipase C (PLC) inositol triphosphate (IP3)/calcium-signaling pathway. The protein product of GRM1, mGlurR1, is neuronally expressed with highest levels in the cerebellum and cortex shown on Northern blot analysis, plus elsewhere in the brain. There is little or no expression of GRM1 in the spinal cord or corpus collosum. GRM5 is capable of agonist-independent/constitutive activity. It is localized pre- and post-synaptically. There is heterologous expression of GRM5 in Xenopus. The protein product of GRM5, mGluR5, activates PLC in response to glutamate. The mGluR5 knock-out mouse shows impaired special learning and reduced long-term potentiation (LTP) in N-methyl-D-aspartate (NMDA) receptor-dependent pathways.