How Long is LTP?

Professor Seth Grant explains that long-term potentiation may last for days or weeks, but is usually studied over the course of several hours.

Long-term potentiation has been reported to last for as long as several weeks. But most of the time investigators study it for the course of an hour or two, in an in vitro situation where there is a brain slice in a culture dish. But in vivo recordings, in the intact animal, have shown it can last for days, and indeed weeks.