COMT expression

Professor Daniel Weinberger explains that the schizophrenia candidate gene, COMT, is abundantly expressed in the hippocampus and prefrontal cortex.

Where is COMT expressed? So COMT is a gene that is turned on and off by the activity of a cell. And the cells that happen to have a lot of COMT in them are particularly the cells of the regions of the brain that are most implicated in schizophrenia - the prefrontal cortex and the hippocampal formation. And so nerve cells, neurons in these two parts of the brain, express, particularly abundantly, COMT.