Professor Jonathan Finch explains that the neurobiology of neuroticism is similar in humans and animal models.
Well, animal models of anxiety are probably meaningful because it seems fairly unlikely that animals don’t get frightened and the likelihood is they get frightened the same ways we do. We know, in fact, that the neurobiology of those two processes is fairly similar. And because there is a fairly large overlap between anxiety and depression in humans, we make the assumption, not entirely proven, that the same applies also in animals.